The binomial coefficient ${\displaystyle (\genfrac{}{}{0ex}{}{{10}^{18}}{{10}^9})}$ is a number with more than $9$ billion ($9\times {10}^9$) digits.

Let $M(n,k,m)$ denote the binomial coefficient ${\displaystyle (\genfrac{}{}{0ex}{}{n}{k})}$ modulo $m$.

Calculate ${\displaystyle \sum M({10}^{18},{10}^9,p\cdot q\cdot r)}$ for $1000<p<q<r<5000$ and $p$,$q$,$r$ prime.